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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1990-6-6
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pubmed:abstractText |
The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-14495438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-171586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-186555,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-207787,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-2582082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-2613230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-2822966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-2826645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-3003382,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-4847746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-6092713,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2159050-6331345
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1469-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2159050-Animals,
pubmed-meshheading:2159050-Crosses, Genetic,
pubmed-meshheading:2159050-Cytomegalovirus,
pubmed-meshheading:2159050-Female,
pubmed-meshheading:2159050-Immunity, Innate,
pubmed-meshheading:2159050-Male,
pubmed-meshheading:2159050-Mice,
pubmed-meshheading:2159050-Mice, Inbred Strains,
pubmed-meshheading:2159050-Recombination, Genetic,
pubmed-meshheading:2159050-Species Specificity,
pubmed-meshheading:2159050-Spleen,
pubmed-meshheading:2159050-Virus Replication
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pubmed:year |
1990
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pubmed:articleTitle |
Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen.
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pubmed:affiliation |
Department of Microbiology, University of Western Australia, Nedlands.
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pubmed:publicationType |
Journal Article
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