Linked Life Data

2157697

Source:http://linkedlifedata.com/resource/pubmed/id/2157697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-5-24
pubmed:abstractText
Sheets of utricular epithelium from gerbil were mounted in a micro-Ussing chamber. Step changes in [Na] and [K] on each side of the epithelium led to changes in transepithelial potential difference (Vt) and resistance (Rt) which were consistent with the presence of ionic conductances for these two ions. Responses of Vt to 20 mM Rb steps were similar to those to 20 mM K steps. Several common Na and K channel blockers were applied: No evidence for the presence of amiloride-sensitive Na channels was found. At 10(-6) M, amiloride caused no significant changes in Vt but at 10(-3) M it initially decreased or increased Vt when applied from the apical or the basolateral side, respectively. Ba and quinidine each reduced Vt, quinidine more strongly from the basolateral than from the apical side. Tetraethylammonium, another K channel blocker, had no significant effect from either side. These data suggest that in spite of the low value of Rt, the cellular pathway contributes significantly to the voltage response to cation concentration steps in this epithelium. The mode of action of 10(-3) M amiloride and the K channel blockers remains uncertain.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0378-5955
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Transepithelial electrical responses to sodium and potassium of nonsensory region of gerbil utricle.
pubmed:affiliation
Washington University Medical School, Department of Ophthalmology, St. Louis, Missouri.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.