Source:http://linkedlifedata.com/resource/pubmed/id/21576624
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-6-16
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| pubmed:abstractText |
Low birth weight has consistently been associated with increased adult blood pressure. The relative importance of childhood growth is, however, less well established. This study examined sex-specific associations between childhood growth and adult blood pressure in 2120 subjects born from 1921 to 1935 in Reykjavik who were recruited into a longitudinal study in 1967-1991. Size at birth and growth at regular intervals between 8 and 13 years were collected from national archives. Hypertensive males did not differ from normotensive males at birth but were increasingly taller and of higher body mass index between 8 and 13 years. No differences in adult height were observed between hypertensive and normotensive males. For boys, growth-velocity (change in growth per year) for body mass index and height between 8 to 13 years was positively associated (P<0.05) with adult blood pressure. The association for body mass index-velocity was fully accounted for by concurrent body size, whereas height-velocity was independent of birth weight and concurrent body size. Males in the highest compared with the lowest tertile in the height-velocity distribution had 66% increased risks of hypertension (95% CI: 15% to 139% increased risks of hypertension) corresponding with 5.0 mm Hg increase (95% CI: 1.5 to 8.5 mm Hg increase) and 3.1 mm Hg increase (95% CI: 1.1 to 5.0 mm Hg increase) in systolic and diastolic blood pressures, respectively. Hypertensive females weighed less at birth but did not differ markedly from normotensive girls between 8 and 13 years, and no association was observed for growth-velocity. In conclusion, rapid linear growth between 8 and 13 years predicts elevated adult blood pressure in boys. This association is likely to reflect relatively early onset of puberty among hypertensive males.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1524-4563
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
58
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
8-15
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| pubmed:meshHeading |
pubmed-meshheading:21576624-Adolescent,
pubmed-meshheading:21576624-Adult,
pubmed-meshheading:21576624-Aged,
pubmed-meshheading:21576624-Birth Weight,
pubmed-meshheading:21576624-Blood Pressure,
pubmed-meshheading:21576624-Body Mass Index,
pubmed-meshheading:21576624-Child,
pubmed-meshheading:21576624-Child, Preschool,
pubmed-meshheading:21576624-Child Development,
pubmed-meshheading:21576624-Disease Progression,
pubmed-meshheading:21576624-Female,
pubmed-meshheading:21576624-Follow-Up Studies,
pubmed-meshheading:21576624-Humans,
pubmed-meshheading:21576624-Hypertension,
pubmed-meshheading:21576624-Iceland,
pubmed-meshheading:21576624-Incidence,
pubmed-meshheading:21576624-Infant,
pubmed-meshheading:21576624-Infant, Newborn,
pubmed-meshheading:21576624-Male,
pubmed-meshheading:21576624-Middle Aged,
pubmed-meshheading:21576624-Overweight,
pubmed-meshheading:21576624-Population Surveillance,
pubmed-meshheading:21576624-Prevalence,
pubmed-meshheading:21576624-Prognosis,
pubmed-meshheading:21576624-Risk Factors,
pubmed-meshheading:21576624-Time Factors,
pubmed-meshheading:21576624-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Childhood growth and adult hypertension in a population of high birth weight.
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| pubmed:affiliation |
Unit for Nutrition Research, University of Iceland and Landspitali University Hospital, Reykjavik, Iceland. tih@hi.is
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|