Linked Life Data

21574593

Source:http://linkedlifedata.com/resource/pubmed/id/21574593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-6-28
pubmed:abstractText
Graphene oxide (GO), the new two-dimensional carbon nanomaterial, is extensively investigated for potential biomedical applications. Thus, it is pertinent to critically evaluate its untoward effects on physiology of tissue systems including blood platelets, the cells responsible for maintenance of hemostasis and thrombus formation. Here we report for the first time that atomically thin GO sheets elicited strong aggregatory response in platelets through activation of Src kinases and release of calcium from intracellular stores. Compounding this, intravenous administration of GO was found to induce extensive pulmonary thromboembolism in mice. Prothrombotic character of GO was dependent on surface charge distribution as reduced GO (RGO) was significantly less effective in aggregating platelets. Our findings raise a concern on putative biomedical applications of GO in the form of diagnostic and therapeutic tools where its prothrombotic property should be carefully investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1936-086X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4987-96
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Thrombus inducing property of atomically thin graphene oxide sheets.
pubmed:affiliation
Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't