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rdf:type |
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lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0008976,
umls-concept:C0013216,
umls-concept:C0030705,
umls-concept:C0036525,
umls-concept:C0871754,
umls-concept:C1518601,
umls-concept:C1522484,
umls-concept:C1527249,
umls-concept:C1540289,
umls-concept:C2698590
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pubmed:issue |
9779
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pubmed:dateCreated |
2011-5-23
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pubmed:databankReference |
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pubmed:abstractText |
Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate reduced-dose chemotherapy options and to seek objective predictors of outcome in frail patients with advanced colorectal cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-10655437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-10744089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-10944126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-11290435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-12177775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-14657227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-15860871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-17287242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-17630037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-17855074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-18349394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-19255311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-19356946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-19713248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-21601694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-21872740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-21872741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-3558716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-6880820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-8433390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21570111-8708718
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1474-547X
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pubmed:author |
pubmed-author:BrewsterAlison EAE,
pubmed-author:FOCUS2 Investigators,
pubmed-author:LangleyRuth ERE,
pubmed-author:MaughanTimothy STS,
pubmed-author:MiddletonGaryG,
pubmed-author:National Cancer Research Institute Colorectal Cancer Clinical Studies...,
pubmed-author:O'MahonyM SineadMS,
pubmed-author:ParmarMaheshM,
pubmed-author:SeymourMatthew TMT,
pubmed-author:ShepherdStephen FSF,
pubmed-author:ThompsonLindsay CLC,
pubmed-author:WasanHarpreet SHS
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
377
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1749-59
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pubmed:dateRevised |
2011-8-29
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pubmed:meshHeading |
pubmed-meshheading:21570111-Adenocarcinoma,
pubmed-meshheading:21570111-Administration, Oral,
pubmed-meshheading:21570111-Adult,
pubmed-meshheading:21570111-Aged,
pubmed-meshheading:21570111-Aged, 80 and over,
pubmed-meshheading:21570111-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:21570111-Colorectal Neoplasms,
pubmed-meshheading:21570111-Deoxycytidine,
pubmed-meshheading:21570111-Disease-Free Survival,
pubmed-meshheading:21570111-Dose-Response Relationship, Drug,
pubmed-meshheading:21570111-Drug Administration Schedule,
pubmed-meshheading:21570111-Female,
pubmed-meshheading:21570111-Fluorouracil,
pubmed-meshheading:21570111-Frail Elderly,
pubmed-meshheading:21570111-Great Britain,
pubmed-meshheading:21570111-Humans,
pubmed-meshheading:21570111-Infusions, Intravenous,
pubmed-meshheading:21570111-Male,
pubmed-meshheading:21570111-Middle Aged,
pubmed-meshheading:21570111-Organoplatinum Compounds,
pubmed-meshheading:21570111-Quality of Life
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pubmed:year |
2011
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pubmed:articleTitle |
Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial.
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pubmed:affiliation |
St James's University Hospital and University of Leeds, Leeds, UK. m.seymour@ncrn.org.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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