Linked Life Data

21565751

Source:http://linkedlifedata.com/resource/pubmed/id/21565751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2011-5-13
pubmed:abstractText
Liver needle biopsies played important role in determining the various forms of chronic hepatitis, the activity of inflammation and the degree of fibrosis. A breakthrough in their evaluation was provided by the so-called Knodell Histology Activity Index (HAI) system, which expressed the dynamics of the process and histological characteristics of therapy response. The HAI system underwent several modifications, the most widely used being the Desmet, Ishak modifications as well as the METAVIR scoring system. These systems examine necroinflammation and degree of fibrosis separately, namely the grade and stage of chronic hepatitis. Determination of fibrosis has become the subject of discussion lately, since the amount of connective tissue deposition (collagen fiber, extracellular matrix) is not clearly identifiable with the stage of chronic hepatitis. Histological evaluation of the liver remains decisive in determining the effect of the various new therapeutic drugs, in particular the protease and polymerase inhibitors of certain nonstructural proteins of the hepatitis C virus. It can be established however, that in recent years liver biopsies have become rather a selective than routine technique.
pubmed:language
hun
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0030-6002
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
856-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[The value of liver biopsy in chronic hepatitis].
pubmed:affiliation
Semmelweis Egyetem, Általános Orvostudományi Kar II. Patológiai Intézet Budapest Üll?i út 93. 1091. schaff@korb2.sote.hu
pubmed:publicationType
Journal Article, English Abstract, Review