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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2011-6-14
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pubmed:abstractText |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons that results in progressive muscle weakness and limits survival to 2-5 years after disease onset. Intermediate CAG repeat expansions in ataxin 2 (ATXN2), the causative gene of spinocerebellar ataxia type 2 (SCA2), have been implicated in sporadic ALS. We studied ATXN2 in a large cohort of patients with sporadic and familial ALS.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2066-72
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pubmed:meshHeading |
pubmed-meshheading:21562247-Adult,
pubmed-meshheading:21562247-Age of Onset,
pubmed-meshheading:21562247-Aged,
pubmed-meshheading:21562247-Aged, 80 and over,
pubmed-meshheading:21562247-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:21562247-Belgium,
pubmed-meshheading:21562247-Female,
pubmed-meshheading:21562247-Humans,
pubmed-meshheading:21562247-Male,
pubmed-meshheading:21562247-Middle Aged,
pubmed-meshheading:21562247-Nerve Tissue Proteins,
pubmed-meshheading:21562247-Netherlands,
pubmed-meshheading:21562247-Pedigree,
pubmed-meshheading:21562247-Spinocerebellar Ataxias,
pubmed-meshheading:21562247-Trinucleotide Repeat Expansion
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pubmed:year |
2011
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pubmed:articleTitle |
Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2.
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pubmed:affiliation |
Department of Neurology, University Hospital Leuven, Leuven, Belgium. wim.robberecht@uzleuven.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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