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pubmed-article:2155728pubmed:abstractTextInfection of mice with murine cytomegalovirus (CMV) presents a model for the study of the role of the immune system in the pathogenesis of human CMV. We performed adoptive transfer experiments to evaluate the prospects for enhancing the anti-viral potential of murine CMV immune spleen cells by THF-gamma 2. Adult BALB/c mice resistant to murine CMV become highly susceptible following immunosuppression by cyclophosphamide. Recipient mice were injected with murine CMV and cyclophosphamide concomitantly, and 24 h later adoptive transfers of syngeneic immune spleen cells were performed. We showed that passive transfers of murine CMV immune spleen cells prevented the development of a fatal disease in 38% of the recipient mice. Daily injections of murine CMV immune donor mice with THF-gamma 2 enhanced considerably (93%) the therapeutic potential of virus-specific immune cells. These experiments provide direct evidence for the antiviral capacity of THF-gamma 2 through its immunomodulatory effect on immune T cells.lld:pubmed
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pubmed-article:2155728pubmed:articleTitleTherapy of a fatal murine cytomegalovirus infection with thymic humoral factor (THF-gamma 2) treated immune spleen cells.lld:pubmed
pubmed-article:2155728pubmed:affiliationDepartment of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel.lld:pubmed
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pubmed-article:2155728pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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