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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-4-23
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pubmed:abstractText |
Infection of mice with murine cytomegalovirus (CMV) presents a model for the study of the role of the immune system in the pathogenesis of human CMV. We performed adoptive transfer experiments to evaluate the prospects for enhancing the anti-viral potential of murine CMV immune spleen cells by THF-gamma 2. Adult BALB/c mice resistant to murine CMV become highly susceptible following immunosuppression by cyclophosphamide. Recipient mice were injected with murine CMV and cyclophosphamide concomitantly, and 24 h later adoptive transfers of syngeneic immune spleen cells were performed. We showed that passive transfers of murine CMV immune spleen cells prevented the development of a fatal disease in 38% of the recipient mice. Daily injections of murine CMV immune donor mice with THF-gamma 2 enhanced considerably (93%) the therapeutic potential of virus-specific immune cells. These experiments provide direct evidence for the antiviral capacity of THF-gamma 2 through its immunomodulatory effect on immune T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-197022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-207997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-2448072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-2536778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-2991554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3003382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3023703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3029272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3041033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3261994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3805719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-3875914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-4121080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-4365945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6207307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6257788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6257800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6260872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6286796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6292342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6296961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6302813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6314141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2155728-6332883
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2155728-Animals,
pubmed-meshheading:2155728-Cyclophosphamide,
pubmed-meshheading:2155728-Cytomegalovirus Infections,
pubmed-meshheading:2155728-Female,
pubmed-meshheading:2155728-Immunization, Passive,
pubmed-meshheading:2155728-Mice,
pubmed-meshheading:2155728-Mice, Inbred BALB C,
pubmed-meshheading:2155728-Mice, Inbred CBA,
pubmed-meshheading:2155728-Spleen,
pubmed-meshheading:2155728-Thymus Hormones
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pubmed:year |
1990
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pubmed:articleTitle |
Therapy of a fatal murine cytomegalovirus infection with thymic humoral factor (THF-gamma 2) treated immune spleen cells.
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pubmed:affiliation |
Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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