Linked Life Data

21547310

Source:http://linkedlifedata.com/resource/pubmed/id/21547310

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2011-6-14
pubmed:abstractText
We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a "bioelectronic super-taster (BST)", a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1473-0189
pubmed:author
pubmed:copyrightInfo
This journal is © The Royal Society of Chemistry 2011
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2262-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
"Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures.
pubmed:affiliation
Department of Chemistry, Soonchunhyang University, Asan, 336-745, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't