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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-3-29
|
| pubmed:abstractText |
Between 1961 and 1985, 62 patients with malignant salivary gland tumors of the oral cavity underwent surgery with curative intent at the University of California, Los Angeles (UCLA) Medical center. All patients had a minimum follow-up of 2 years. Fifty of 62 (81%) patients presented with T1-2 primary tumors. The tumors arose from the palate in 41/62 (66%) patients. The most common histologic type was adenoid cystic carcinoma comprising 34 of 62 (55%) cases. Radical resection was performed in 46 cases and wide local excision in 16 patients. Postoperative radiation therapy was used in 24 cases due to advanced stage and/or positive surgical margins. Results of treatment were analyzed by stage of disease, modes of treatment, histology, and surgical extent. Local control of small lesions reached 100% at 10 years with either radical resection alone or local excision. With residual tumor at the surgical margins, the incidence of local recurrence was 4/14 (29%) for those who received adjuvant radiation therapy and 5/10 (50%) for those who did not. The vast majority of mucoepidermoid carcinomas were early stage and low grade. These lesions had an excellent prognosis with a control rate of 100%. In contrast, there was a 29% (10/34) failure rate for adenoid cystic carcinoma. The 5-, 10-, and 15-year actuarial survivals for the whole group were 94%, 84%, and 73%, respectively. Our results indicate that for early stage disease, wide local excision may offer patients the chance to avoid the cosmetically and functionally debilitating effects of radical surgery without compromising treatment outcome. Adjuvant radiation therapy appears to reduce the local recurrence for those with residual tumor at the surgical margins.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0360-3016
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
413-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2154422-Adolescent,
pubmed-meshheading:2154422-Adult,
pubmed-meshheading:2154422-Aged,
pubmed-meshheading:2154422-Carcinoma,
pubmed-meshheading:2154422-Carcinoma, Adenoid Cystic,
pubmed-meshheading:2154422-Combined Modality Therapy,
pubmed-meshheading:2154422-Female,
pubmed-meshheading:2154422-Follow-Up Studies,
pubmed-meshheading:2154422-Humans,
pubmed-meshheading:2154422-Male,
pubmed-meshheading:2154422-Middle Aged,
pubmed-meshheading:2154422-Prognosis,
pubmed-meshheading:2154422-Salivary Gland Neoplasms,
pubmed-meshheading:2154422-Salivary Glands, Minor
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Salivary gland tumors of the oral cavity.
|
| pubmed:affiliation |
Radiation Therapy Service, VA Medical Center, West Los Angeles, CA 90073.
|
| pubmed:publicationType |
Journal Article
|