Linked Life Data

21540127

Source:http://linkedlifedata.com/resource/pubmed/id/21540127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-6-6
pubmed:abstractText
Pathological mitochondrial DNA (mtDNA) rearrangements have been proposed to result from repair of double-strand breaks caused by blockage of mitochondrial DNA (mtDNA) replication. As mtDNA deletions are seen only in post-mitotic tissues, it has been suggested that they are selected out in actively dividing cells. By electron microscopy we observed rearranged mtDNA molecules in cultured human cells expressing a catalytically impaired helicase. As these molecules were undetectable by PCR, we propose that deleted mtDNA molecules in cultured cells are fragile and sensitive to heating. Further consequences of mtDNA replication stalling are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1872-8278
pubmed:author
pubmed:copyrightInfo
© 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
630-4
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Replication stalling by catalytically impaired Twinkle induces mitochondrial DNA rearrangements in cultured cells.
pubmed:affiliation
Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany. Jaakko.Pohjoismaeki@mpi-bn.mpg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't