Linked Life Data

2153384

Source:http://linkedlifedata.com/resource/pubmed/id/2153384

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-3-14
pubmed:abstractText
Isolation of infectious viruses from the brain during a chronic neurological disease is infrequent because persistent viruses differ from the parental virus in their virulence and in the development in genomic or replication defects. We have isolated mouse hepatitis virus 3 (MHV3) variants from the brain of chronically infected mice up to 105 days postinfection by culture on overconfluent L2 cells. In spite of atrophy and leukopenia observed in lymphoid organs of these mice, no viruses were isolated in numerous attempts. In contrast, defective-interfering viruses were detected in peritoneal exudate cells from chronically-infected mice. Brain-derived viruses differ from parental virus in their delayed fusion activity and attenuated pathogenicity for C57BL/6 and A/J mice. The attenuated brain isolates have ceased to replicate in thymocytes but replicated in nonadherent spleen and peritoneal exudate cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0882-8245
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Immune cell tropisms of attenuated MHV3 viruses isolated from brains of chronically infected mice.
pubmed:affiliation
Department of Sciences Biologiques, Université du Québec à Montréal, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't