Source:http://linkedlifedata.com/resource/pubmed/id/21531000
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2011-9-29
|
| pubmed:abstractText |
Hepatocyte growth factor has been identified as a lymphangiogenic factor in experimental animal models. However, the correlation between hepatocyte growth factor or c-Met expression and lymphangiogenesis in human spontaneous tumors has been rarely reported, and the distribution pattern of c-Met on tumor-related lymphatic vessels remains to be further investigated. Lymphatic vessel density, lymphatic invasion, the expression of hepatocyte growth factor, c-Met, and vascular endothelial growth factor C proteins were evaluated by immunohistochemistry in 76 cases of oral squamous cell carcinoma. The distribution of c-Met on lymphatic endothelium was examined. High expression of c-Met in tumor cells was significantly associated with advanced clinical stage (P = .045), high expression of vascular endothelial growth factor-C (P < .001), higher peritumoral lymphatic vessel density (P = .003), higher incidence of peritumoral lymphatic invasion (P = .032), and positive lymph node status (P = .005), in spite of its negative expression on most lymphatic vessels. Patients with high-c-Met expression tumors exhibited shorter overall survival and disease-free survival (P < .001 and P = .010, respectively). Taken together, our results provide indirect evidence for an association and possible regulatory link of c-Met with the lymphangiogenic factor, vascular endothelial growth factor C, and, by extension, with lymphangiogenesis and lymph node metastasis, suggesting important prognostic significance of c-Met for patients with oral squamous cell carcinoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor C
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1532-8392
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1514-23
|
| pubmed:meshHeading |
pubmed-meshheading:21531000-Carcinoma, Squamous Cell,
pubmed-meshheading:21531000-Endothelial Cells,
pubmed-meshheading:21531000-Endothelium, Lymphatic,
pubmed-meshheading:21531000-Female,
pubmed-meshheading:21531000-Hepatocyte Growth Factor,
pubmed-meshheading:21531000-Humans,
pubmed-meshheading:21531000-Lymphangiogenesis,
pubmed-meshheading:21531000-Lymphatic Metastasis,
pubmed-meshheading:21531000-Lymphatic Vessels,
pubmed-meshheading:21531000-Male,
pubmed-meshheading:21531000-Mouth Neoplasms,
pubmed-meshheading:21531000-Neoplasm Recurrence, Local,
pubmed-meshheading:21531000-Prognosis,
pubmed-meshheading:21531000-Proto-Oncogene Proteins c-met,
pubmed-meshheading:21531000-Survival Analysis,
pubmed-meshheading:21531000-Tumor Markers, Biological,
pubmed-meshheading:21531000-Vascular Endothelial Growth Factor C
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Intratumoral c-Met expression is associated with vascular endothelial growth factor C expression, lymphangiogenesis, and lymph node metastasis in oral squamous cell carcinoma: implications for use as a prognostic marker.
|
| pubmed:affiliation |
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, PR China.
|
| pubmed:publicationType |
Journal Article
|