Linked Life Data

2152977

Source:http://linkedlifedata.com/resource/pubmed/id/2152977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-8
pubmed:abstractText
The major difficulty in defining the mechanisms for the action of food restriction relates to its diversity and lack of specificity. In searching for the common factor(s) and commonality involved in such diversified effects, a cellular homeostasis mechanism is proposed. A study initiated in our laboratory strongly indicates that the cellular homeostatic mechanism is seriously compromised by oxidative damage of free radical reaction with aging. Data on mitochondrial hydroperoxide, microsomal cytochrome P-450 breakdown, and reduction of cytosolic antioxidant capacity support the notion. Remarkably, food restriction attenuates all of these age-related changes. It is concluded therefore that food restriction preserves the homeostatic regulatory processes by maintaining the integrity of (i) membrane structure and function, (ii) proper redox state of cellular components, and (iii) detoxification process of xenobiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
193
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-5
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Mechanism of food restriction: protection of cellular homeostasis.
pubmed:affiliation
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
pubmed:publicationType
Journal Article