Linked Life Data

21527308

Source:http://linkedlifedata.com/resource/pubmed/id/21527308

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pubmed-article:21527308pubmed:abstractTextInvestigations on the role of intracellular Ca(2+) ion concentration in the mechanism of development of COPD in smokers and non-smokers were carried out. The intracellular Ca(2+) levels were found to be increased in human lymphocytes in patients with COPD as compared to non-smokers and smokers without COPD. The investigations reveal an association in altered intracellular Ca(2+) regulation in lymphocytes and severity of COPD, by means of significant activation of Protein kinase C and inducible nitric oxide synthase (iNOS). The effect of a novel calcium channel blocker ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate (H-DHPM) as a potential candidate for the treatment of COPD was also investigated. H-DHPM treated cells showed a decrease in intracellular Ca(2+) level as compared to the control cells. Molecular studies were carried out to evaluate the expression profile of NOS isoforms in human lymphocytes and it was shown that H-DHPM decreases the increased iNOS in COPD along with reestablishing the normal levels of endothelial nitric oxide synthase (eNOS). The results of H-DHPM were comparable with those of Amlodipine, a known calcium channel blocker. Calcium channel blocker H-DHPM proves to be a potential candidate for the treatment of COPD and further clinical studies are required to prove its role in the treatment of pulmonary hypertension (PH).lld:pubmed
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pubmed-article:21527308pubmed:copyrightInfoCopyright © 2011 Elsevier Masson SAS. All rights reserved.lld:pubmed
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pubmed-article:21527308pubmed:year2011lld:pubmed
pubmed-article:21527308pubmed:articleTitleNormalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM.lld:pubmed
pubmed-article:21527308pubmed:affiliationDepartment of Biochemistry, VP Chest Institute, University of Delhi, Delhi, India.lld:pubmed
pubmed-article:21527308pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21527308pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed