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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-6
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pubmed:abstractText |
Investigations on the role of intracellular Ca(2+) ion concentration in the mechanism of development of COPD in smokers and non-smokers were carried out. The intracellular Ca(2+) levels were found to be increased in human lymphocytes in patients with COPD as compared to non-smokers and smokers without COPD. The investigations reveal an association in altered intracellular Ca(2+) regulation in lymphocytes and severity of COPD, by means of significant activation of Protein kinase C and inducible nitric oxide synthase (iNOS). The effect of a novel calcium channel blocker ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate (H-DHPM) as a potential candidate for the treatment of COPD was also investigated. H-DHPM treated cells showed a decrease in intracellular Ca(2+) level as compared to the control cells. Molecular studies were carried out to evaluate the expression profile of NOS isoforms in human lymphocytes and it was shown that H-DHPM decreases the increased iNOS in COPD along with reestablishing the normal levels of endothelial nitric oxide synthase (eNOS). The results of H-DHPM were comparable with those of Amlodipine, a known calcium channel blocker. Calcium channel blocker H-DHPM proves to be a potential candidate for the treatment of COPD and further clinical studies are required to prove its role in the treatment of pulmonary hypertension (PH).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1638-6183
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pubmed:author |
pubmed-author:AryaPragyaP,
pubmed-author:AtaçF BFB,
pubmed-author:BansalSurendra KSK,
pubmed-author:BhatiaSumatiS,
pubmed-author:ChatterjeeSuvroS,
pubmed-author:ChaudhuryNabo KNK,
pubmed-author:DePassAnthony LAL,
pubmed-author:DhawanAshishA,
pubmed-author:GangopadhyaySukanyaS,
pubmed-author:JoshiRiniR,
pubmed-author:KumarAjitA,
pubmed-author:ManralSushmaS,
pubmed-author:ParmarVirinder SVS,
pubmed-author:PrasadAshok KAK,
pubmed-author:RajHanumantharao GHG,
pubmed-author:RohilVishwajeetV,
pubmed-author:SasoLucianoL,
pubmed-author:SinhaRajeshR,
pubmed-author:SreedharaSreerama CSC,
pubmed-author:VijayanVannan KVK
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1146-56
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pubmed:meshHeading |
pubmed-meshheading:21527308-Calcium,
pubmed-meshheading:21527308-Calcium Channel Blockers,
pubmed-meshheading:21527308-Cell Line,
pubmed-meshheading:21527308-Cells, Cultured,
pubmed-meshheading:21527308-Chelating Agents,
pubmed-meshheading:21527308-Egtazic Acid,
pubmed-meshheading:21527308-Female,
pubmed-meshheading:21527308-Flow Cytometry,
pubmed-meshheading:21527308-Humans,
pubmed-meshheading:21527308-Intracellular Space,
pubmed-meshheading:21527308-Lymphocytes,
pubmed-meshheading:21527308-Male,
pubmed-meshheading:21527308-Microscopy, Fluorescence,
pubmed-meshheading:21527308-Middle Aged,
pubmed-meshheading:21527308-Molecular Structure,
pubmed-meshheading:21527308-Nitric Oxide,
pubmed-meshheading:21527308-Nitric Oxide Synthase Type II,
pubmed-meshheading:21527308-Nitric Oxide Synthase Type III,
pubmed-meshheading:21527308-Protein Kinase C,
pubmed-meshheading:21527308-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:21527308-Pyrimidinones,
pubmed-meshheading:21527308-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21527308-Signal Transduction,
pubmed-meshheading:21527308-Smoking
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pubmed:year |
2011
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pubmed:articleTitle |
Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM.
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pubmed:affiliation |
Department of Biochemistry, VP Chest Institute, University of Delhi, Delhi, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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