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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2011-5-20
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pubmed:abstractText |
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AbbotSarahS,
pubmed-author:AliantiMM,
pubmed-author:AroraNidhiN,
pubmed-author:ArzenoHumbertoH,
pubmed-author:BilledeauRolandR,
pubmed-author:BlokP GPG,
pubmed-author:DewdneyNolanN,
pubmed-author:DurkinKieranK,
pubmed-author:FrauchigerSandraS,
pubmed-author:GabrielTobiasT,
pubmed-author:GhateManjiriM,
pubmed-author:GoldsteinDavid MDM,
pubmed-author:HillRonald JRJ,
pubmed-author:KuglstatterAndreasA,
pubmed-author:LiFujunF,
pubmed-author:McCalebKristenK,
pubmed-author:McIntoshJoelJ,
pubmed-author:MussII,
pubmed-author:ParkJaehyeonJ,
pubmed-author:SothMichaelM,
pubmed-author:StahlMartinM,
pubmed-author:SungMan-LingML,
pubmed-author:SuttmanRebeccaR,
pubmed-author:SwinneyDavid CDC,
pubmed-author:WellerPaulP,
pubmed-author:WongBrianB,
pubmed-author:ZecicHasimH
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3452-6
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pubmed:meshHeading |
pubmed-meshheading:21515047-Animals,
pubmed-meshheading:21515047-Crystallography, X-Ray,
pubmed-meshheading:21515047-Drug Design,
pubmed-meshheading:21515047-Enzyme Activation,
pubmed-meshheading:21515047-Enzyme Inhibitors,
pubmed-meshheading:21515047-Inhibitory Concentration 50,
pubmed-meshheading:21515047-Mitogen-Activated Protein Kinase 14,
pubmed-meshheading:21515047-Models, Molecular,
pubmed-meshheading:21515047-Molecular Structure,
pubmed-meshheading:21515047-Pyrazoles,
pubmed-meshheading:21515047-Pyrimidines,
pubmed-meshheading:21515047-Rats
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pubmed:year |
2011
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pubmed:articleTitle |
3-Amino-pyrazolo[3,4-d]pyrimidines as p38? kinase inhibitors: design and development to a highly selective lead.
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pubmed:affiliation |
Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. michael.soth@roche.com
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pubmed:publicationType |
Journal Article
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