Linked Life Data

21510614

Source:http://linkedlifedata.com/resource/pubmed/id/21510614

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2011-5-13
pubmed:abstractText
A novel ion pair catalyst containing a chiral counteranion can be readily derived by simply mixing cinchona alkaloid-derived diamine with chiral camphorsulfonic acid (CSA). A mixture of 9-amino(9-deoxy)epi-quinine 8 and (-)-CSA was found to be the best catalyst with matching chirality, enabling the direct amination of ?-branched aldehydes to proceed in quantitative yields and with nearly perfect enantioselectivities. A 0.5 mol % catalyst loading was sufficient to catalyze the reaction, and a gram scale enantioselective synthesis of biologically important ?-methyl phenylglycine has been successfully demonstrated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1523-7052
pubmed:author
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2638-41
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Primary amine/CSA ion pair: a powerful catalytic system for the asymmetric enamine catalysis.
pubmed:affiliation
Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Singapore.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't