21508099

Source:http://linkedlifedata.com/resource/pubmed/id/21508099

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005528, umls-concept:C0017817, umls-concept:C0033268, umls-concept:C0124869, umls-concept:C1426025, umls-concept:C2330894, umls-concept:C2349975
pubmed:issue	8
pubmed:dateCreated	2011-8-1
pubmed:abstractText	To evaluate the role of SLC5A8 in the transport of 2-oxothiazolidine-4-carboxylate (OTC) and to determine whether OTC augments glutathione production in RPE cells, thereby providing protection against oxidative stress.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/K99/R00 EY018053
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7703701
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2-oxothiazolidine-4-carboxylic acid, http://linkedlifedata.com/resource/pubmed/chemical/Cation Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione, http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide, http://linkedlifedata.com/resource/pubmed/chemical/Ibuprofen, http://linkedlifedata.com/resource/pubmed/chemical/Oxidants, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidonecarboxylic Acid, http://linkedlifedata.com/resource/pubmed/chemical/SLC5A8 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Slc5a8 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidines
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1552-5783
pubmed:author	pubmed-author:AnanthSudhaS, pubmed-author:BabuEllappanE, pubmed-author:BoettgerThomasT, pubmed-author:CoothankandaswamyVeenaV, pubmed-author:GanapathyVadivelV, pubmed-author:MartinPamela MPM, pubmed-author:SmithSylvia BSB, pubmed-author:Veeranan-KarmegamRajalakshmiR
pubmed:issnType	Electronic
pubmed:volume	52
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5749-57
pubmed:dateRevised	2011-9-30
pubmed:meshHeading	pubmed-meshheading:21508099-Animals, pubmed-meshheading:21508099-Apoptosis, pubmed-meshheading:21508099-Biological Transport, pubmed-meshheading:21508099-Cation Transport Proteins, pubmed-meshheading:21508099-Cell Survival, pubmed-meshheading:21508099-Cyclooxygenase Inhibitors, pubmed-meshheading:21508099-Drug Interactions, pubmed-meshheading:21508099-Glutathione, pubmed-meshheading:21508099-Humans, pubmed-meshheading:21508099-Hydrogen Peroxide, pubmed-meshheading:21508099-Ibuprofen, pubmed-meshheading:21508099-Kinetics, pubmed-meshheading:21508099-Mice, pubmed-meshheading:21508099-Mice, Mutant Strains, pubmed-meshheading:21508099-Oocytes, pubmed-meshheading:21508099-Oxidants, pubmed-meshheading:21508099-Oxidative Stress, pubmed-meshheading:21508099-Pyrrolidonecarboxylic Acid, pubmed-meshheading:21508099-Retinal Pigment Epithelium, pubmed-meshheading:21508099-Thiazolidines, pubmed-meshheading:21508099-Xenopus laevis
pubmed:year	2011
pubmed:articleTitle	Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.
pubmed:affiliation	Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural