Linked Life Data

21504716

Source:http://linkedlifedata.com/resource/pubmed/id/21504716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-4-20
pubmed:abstractText
Distinguishing mantle cell lymphoma (MCL), from low-grade B-cell lymphoma is important because MCL is clinically more aggressive and is treated differently. Though most MCL overexpress cyclinD1 (CCND1) and have a t(11;14)(q13;q32), MCL that are negative for CCND1 exist. Some have translocations involving cyclinD2 (CCND2) and either the immunoglobulin heavy chain or kappa light chain locus. We present a CD5-positive, CCND1-negative B-cell lymphoma with a novel translocation involving CCND2 and the immunoglobulin lambda (IGL) gene. A 64-year-old male underwent resection of a polypoid mass of the ileum. Histology showed atypical, medium-sized lymphoid cells positive for CD20, CD5, CD43, and CCND2 by immunohistochemistry, and negative for CCND1, CCND3, and p27. Fluorescence in situ hybridization was negative for CCND1 abnormalities, but demonstrated a CCND2/IGL fusion. Clinical workup revealed stage IV disease. Current diagnostic criteria are insufficient for subclassifying this case, highlighting the need for additional studies on CCND2-translocated B-cell lymphomas to guide therapy appropriately.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
2210-7762
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Print
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
162-4
pubmed:meshHeading
pubmed-meshheading:21504716-Antigens, CD5, pubmed-meshheading:21504716-Bone Marrow Neoplasms, pubmed-meshheading:21504716-Chromosomes, Human, Pair 12, pubmed-meshheading:21504716-Chromosomes, Human, Pair 22, pubmed-meshheading:21504716-Cyclin D1, pubmed-meshheading:21504716-Cyclin D2, pubmed-meshheading:21504716-Diagnosis, Differential, pubmed-meshheading:21504716-Gastrointestinal Neoplasms, pubmed-meshheading:21504716-Humans, pubmed-meshheading:21504716-Immunoglobulin lambda-Chains, pubmed-meshheading:21504716-Immunohistochemistry, pubmed-meshheading:21504716-In Situ Hybridization, Fluorescence, pubmed-meshheading:21504716-Lymphoma, B-Cell, pubmed-meshheading:21504716-Lymphoma, Mantle-Cell, pubmed-meshheading:21504716-Male, pubmed-meshheading:21504716-Middle Aged, pubmed-meshheading:21504716-Translocation, Genetic
pubmed:year
2011
pubmed:articleTitle
CD5-positive, cyclinD1-negative mantle cell lymphoma with a translocation involving the CCND2 gene and the IGL locus.
pubmed:affiliation
Department of Pathology, Baylor University Medical Center, Dallas, TX, USA. michelleshiller@yahoo.com
pubmed:publicationType
Journal Article, Case Reports