Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-26
pubmed:abstractText
Widespread death of implanted cells hampers the development of stem cell therapy for acute myocardial infarction (AMI). Our previous studies indicated that statins can protect implanted mesenchymal stem cells (MSCs) against the post-infarct microenvironment, thus increasing the therapeutic effect. However, the underlying mechanisms are unclear. The JAK-STAT pathway participates in regulation of stress responses of the myocardium to various insults. This study aimed to detect whether rosuvastatin (ROSU) facilitates the survival, engraftment, and differentiation of allogeneic bone marrow-derived MSCs in the post-infarct heart via the JAK-STAT signaling pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA..., http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides, http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins, http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyano-(3,4-dihydroxy)-N-benzyl..., http://linkedlifedata.com/resource/pubmed/chemical/rosuvastatin
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1347-4820
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1476-85
pubmed:meshHeading
pubmed-meshheading:21502705-Animals, pubmed-meshheading:21502705-Cell Differentiation, pubmed-meshheading:21502705-Cell Survival, pubmed-meshheading:21502705-Cell Tracking, pubmed-meshheading:21502705-Cells, Cultured, pubmed-meshheading:21502705-Disease Models, Animal, pubmed-meshheading:21502705-Enzyme Activation, pubmed-meshheading:21502705-Female, pubmed-meshheading:21502705-Fluorobenzenes, pubmed-meshheading:21502705-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:21502705-Janus Kinase 2, pubmed-meshheading:21502705-Male, pubmed-meshheading:21502705-Mesenchymal Stem Cell Transplantation, pubmed-meshheading:21502705-Mesenchymal Stem Cells, pubmed-meshheading:21502705-Myocardial Contraction, pubmed-meshheading:21502705-Myocardial Infarction, pubmed-meshheading:21502705-Myocardium, pubmed-meshheading:21502705-Phosphorylation, pubmed-meshheading:21502705-Protein Kinase Inhibitors, pubmed-meshheading:21502705-Pyrimidines, pubmed-meshheading:21502705-Rats, pubmed-meshheading:21502705-Rats, Sprague-Dawley, pubmed-meshheading:21502705-Recovery of Function, pubmed-meshheading:21502705-STAT3 Transcription Factor, pubmed-meshheading:21502705-Signal Transduction, pubmed-meshheading:21502705-Stroke Volume, pubmed-meshheading:21502705-Sulfonamides, pubmed-meshheading:21502705-Time Factors, pubmed-meshheading:21502705-Transplantation, Homologous, pubmed-meshheading:21502705-Tyrphostins, pubmed-meshheading:21502705-Ventricular Function, Left, pubmed-meshheading:21502705-Y Chromosome
pubmed:year
2011
pubmed:articleTitle
Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts.
pubmed:affiliation
Center for Coronary Heart Disease, Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't