rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2011-5-26
|
pubmed:abstractText |
Widespread death of implanted cells hampers the development of stem cell therapy for acute myocardial infarction (AMI). Our previous studies indicated that statins can protect implanted mesenchymal stem cells (MSCs) against the post-infarct microenvironment, thus increasing the therapeutic effect. However, the underlying mechanisms are unclear. The JAK-STAT pathway participates in regulation of stress responses of the myocardium to various insults. This study aimed to detect whether rosuvastatin (ROSU) facilitates the survival, engraftment, and differentiation of allogeneic bone marrow-derived MSCs in the post-infarct heart via the JAK-STAT signaling pathway.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyano-(3,4-dihydroxy)-N-benzyl...,
http://linkedlifedata.com/resource/pubmed/chemical/rosuvastatin
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1347-4820
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
25
|
pubmed:volume |
75
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1476-85
|
pubmed:meshHeading |
pubmed-meshheading:21502705-Animals,
pubmed-meshheading:21502705-Cell Differentiation,
pubmed-meshheading:21502705-Cell Survival,
pubmed-meshheading:21502705-Cell Tracking,
pubmed-meshheading:21502705-Cells, Cultured,
pubmed-meshheading:21502705-Disease Models, Animal,
pubmed-meshheading:21502705-Enzyme Activation,
pubmed-meshheading:21502705-Female,
pubmed-meshheading:21502705-Fluorobenzenes,
pubmed-meshheading:21502705-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:21502705-Janus Kinase 2,
pubmed-meshheading:21502705-Male,
pubmed-meshheading:21502705-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:21502705-Mesenchymal Stem Cells,
pubmed-meshheading:21502705-Myocardial Contraction,
pubmed-meshheading:21502705-Myocardial Infarction,
pubmed-meshheading:21502705-Myocardium,
pubmed-meshheading:21502705-Phosphorylation,
pubmed-meshheading:21502705-Protein Kinase Inhibitors,
pubmed-meshheading:21502705-Pyrimidines,
pubmed-meshheading:21502705-Rats,
pubmed-meshheading:21502705-Rats, Sprague-Dawley,
pubmed-meshheading:21502705-Recovery of Function,
pubmed-meshheading:21502705-STAT3 Transcription Factor,
pubmed-meshheading:21502705-Signal Transduction,
pubmed-meshheading:21502705-Stroke Volume,
pubmed-meshheading:21502705-Sulfonamides,
pubmed-meshheading:21502705-Time Factors,
pubmed-meshheading:21502705-Transplantation, Homologous,
pubmed-meshheading:21502705-Tyrphostins,
pubmed-meshheading:21502705-Ventricular Function, Left,
pubmed-meshheading:21502705-Y Chromosome
|
pubmed:year |
2011
|
pubmed:articleTitle |
Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts.
|
pubmed:affiliation |
Center for Coronary Heart Disease, Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|