Source:http://linkedlifedata.com/resource/pubmed/id/21501091
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7-8
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| pubmed:dateCreated |
2011-7-18
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| pubmed:abstractText |
Abstract This study investigated the anxiolytic-like effects of 4-O-methylhonokiol, a neolignan compound of Magnolia officinalis, by using the experimental paradigms of anxiety and compared the results with those of a known anxiolytic, diazepam. A single treatment with 4-O-methylhonokiol (0.1, 0.2, and 0.5 mg/kg, p.o.) or treatment for 7 days (0.5 mg/kg in drinking water) increased the percentage of time spent in the open arms and the number of open arms entries in the elevated plus-maze test. However, the 4-O-methylhonokiol-increased percentage of time spent in the open arm was abolished by treatment with flumazenil, a benzodiazepine receptor antagonist (10 mg/kg). 4-O-Methylhonokiol also increased the number of head dips in the hole-board test, but decreased locomotor activity. Molecular experiments revealed that the ?1-subunit of ?-aminobutyric acid (GABA) type A receptors was overexpressed in the cortex of brains of mice after treatment with 4-O-methylhonokiol for 7 days. In addition, 4-O-methylhonokiol also increased chloride influx in cultured cortical cells. It is concluded that 4-O-methylhonokiol may have anxiolytic-like effects and that these effects may be mediated by GABAergic transmission with the increase of Cl(-) channel opening.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-O-methylhonokiol,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Lignans,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1557-7600
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
724-31
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| pubmed:meshHeading |
pubmed-meshheading:21501091-Animals,
pubmed-meshheading:21501091-Anti-Anxiety Agents,
pubmed-meshheading:21501091-Anxiety,
pubmed-meshheading:21501091-Biological Transport,
pubmed-meshheading:21501091-Biphenyl Compounds,
pubmed-meshheading:21501091-Brain,
pubmed-meshheading:21501091-Chlorides,
pubmed-meshheading:21501091-Disease Models, Animal,
pubmed-meshheading:21501091-Humans,
pubmed-meshheading:21501091-Lignans,
pubmed-meshheading:21501091-Magnolia,
pubmed-meshheading:21501091-Male,
pubmed-meshheading:21501091-Maze Learning,
pubmed-meshheading:21501091-Mice,
pubmed-meshheading:21501091-Mice, Inbred ICR,
pubmed-meshheading:21501091-Motor Activity,
pubmed-meshheading:21501091-Plant Extracts,
pubmed-meshheading:21501091-Rats,
pubmed-meshheading:21501091-Rats, Sprague-Dawley,
pubmed-meshheading:21501091-Receptors, GABA-A,
pubmed-meshheading:21501091-gamma-Aminobutyric Acid
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| pubmed:articleTitle |
Anxiolytic-like effects of 4-O-methylhonokiol isolated from Magnolia officinalis through enhancement of GABAergic transmission and chloride influx.
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| pubmed:affiliation |
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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