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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-16
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pubmed:abstractText |
Calcific aortic valve disease is similar to atherosclerosis in that both diseases result from chronic inflammation and endothelial dysfunction. Heterozygous NOTCH1 mutations have been associated to calcific aortic disease and a bicuspid aortic valve. We investigated whether mice with genetic inactivation of the Notch signaling pathway are prone to develop valve disease when exposed to a predisposing diet.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Hey1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin J Recombination...,
http://linkedlifedata.com/resource/pubmed/chemical/Notch1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Rbpj protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch1,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin D
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1580-8
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pubmed:meshHeading |
pubmed-meshheading:21493891-Analysis of Variance,
pubmed-meshheading:21493891-Animals,
pubmed-meshheading:21493891-Aortic Valve,
pubmed-meshheading:21493891-Calcinosis,
pubmed-meshheading:21493891-Cell Cycle Proteins,
pubmed-meshheading:21493891-Cells, Cultured,
pubmed-meshheading:21493891-Cholesterol, Dietary,
pubmed-meshheading:21493891-Disease Models, Animal,
pubmed-meshheading:21493891-Echocardiography, Doppler,
pubmed-meshheading:21493891-Fibrosis,
pubmed-meshheading:21493891-Gene Expression Regulation,
pubmed-meshheading:21493891-Genotype,
pubmed-meshheading:21493891-Haploinsufficiency,
pubmed-meshheading:21493891-Heart Valve Diseases,
pubmed-meshheading:21493891-Hemodynamics,
pubmed-meshheading:21493891-Heterozygote,
pubmed-meshheading:21493891-Hypercholesterolemia,
pubmed-meshheading:21493891-Immunoglobulin J Recombination Signal Sequence-Binding...,
pubmed-meshheading:21493891-Immunohistochemistry,
pubmed-meshheading:21493891-Mice,
pubmed-meshheading:21493891-Mice, Knockout,
pubmed-meshheading:21493891-Osteogenesis,
pubmed-meshheading:21493891-Phenotype,
pubmed-meshheading:21493891-Receptor, Notch1,
pubmed-meshheading:21493891-Signal Transduction,
pubmed-meshheading:21493891-Stroke Volume,
pubmed-meshheading:21493891-Swine,
pubmed-meshheading:21493891-Ventricular Function,
pubmed-meshheading:21493891-Vitamin D
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pubmed:year |
2011
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pubmed:articleTitle |
Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
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pubmed:affiliation |
Cardiovascular Developmental Biology Department, Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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