|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2011-7-4
|
|
pubmed:abstractText |
High blood flow induces neointimal atrophy in polytetrafluoroethylene (PTFE) aortoiliac grafts and a tight external PTFE wrap of the iliac artery induces medial atrophy. In both nonhuman primate models, atrophy with loss of smooth muscle cells and extracellular matrix (ECM) begins at ?4 days. We hypothesized that matrix loss would be linked to cell death, but the factors and mechanisms involved are not known. The purpose of this study was to determine commonly regulated genes in these two models, which we hypothesized would be a small set of genes that might be key regulators of vascular atrophy.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1097-6809
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
182-191.e24
|
|
pubmed:meshHeading |
pubmed-meshheading:21493032-Animals,
pubmed-meshheading:21493032-Apoptosis,
pubmed-meshheading:21493032-Arteriovenous Shunt, Surgical,
pubmed-meshheading:21493032-Atrophy,
pubmed-meshheading:21493032-Blood Vessel Prosthesis Implantation,
pubmed-meshheading:21493032-Cells, Cultured,
pubmed-meshheading:21493032-Disease Models, Animal,
pubmed-meshheading:21493032-Extracellular Matrix,
pubmed-meshheading:21493032-Fas Ligand Protein,
pubmed-meshheading:21493032-Femoral Artery,
pubmed-meshheading:21493032-Femoral Vein,
pubmed-meshheading:21493032-Gene Expression Profiling,
pubmed-meshheading:21493032-Gene Expression Regulation,
pubmed-meshheading:21493032-Iliac Artery,
pubmed-meshheading:21493032-Male,
pubmed-meshheading:21493032-Muscle, Smooth, Vascular,
pubmed-meshheading:21493032-Myocytes, Smooth Muscle,
pubmed-meshheading:21493032-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21493032-Papio,
pubmed-meshheading:21493032-Postoperative Complications,
pubmed-meshheading:21493032-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21493032-Time Factors
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy.
|
|
pubmed:affiliation |
Department of Surgery, University of Washington, Seattle, WA 98195-6410, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
