Linked Life Data

21492740

Source:http://linkedlifedata.com/resource/pubmed/id/21492740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13-14
pubmed:dateCreated
2011-5-3
pubmed:abstractText
Fractalkine is a unique chemokine which has both adhesive and chemoattractant functions. With the increasing emphasis on the importance of inflammation in atherosclerosis, more attention has been focused on the role of chemokines in atherosclerosis. It has been shown that fractalkine/CX3CR1 participates in the atherosclerotic pathological process through mediating the recruitment of leukocytes and the interaction of vascular cells and leukocytes. Some signal pathways are simultaneously activated through fractalkine/CX3CR1 coupling to promote the inflammatory response in atherosclerotic vessels. Additionally, fractalkine has cytotoxic effects on endothelium as well as anti-apoptosis and proliferative effects on vascular cells which consequently changes plaque components and stability in plaque. Several studies have showed that fractalkine or CX3CR1 deficiency in atherosclerotic mice would ameliorate the severity of plaque. Population studies on CX3CR1 polymorphism have confirmed that 280M-containing haplotype is associated with reduced risk of atherosclerotic disease. Despite the apparent association with atherosclerosis, further studies on fractalkine/CX3CR1 chemokine pair are clearly warranted to more fully elucidate this relationship.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-3492
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
412
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1180-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Fractalkine/CX3CR1 and atherosclerosis.
pubmed:affiliation
Department of Geriatrics, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. katharinehong@163.com
pubmed:publicationType
Journal Article, Review