Source:http://linkedlifedata.com/resource/pubmed/id/21492351
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-4-15
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| pubmed:abstractText |
Heart transplantation is an increasingly acceptable therapeutic option for children with end-stage and complex congenital heart disease. With advances in surgery, immunosuppression, and follow-up care, functional outcomes need to be evaluated. We report the results of serial exercise testing performed using stress echocardiography in a cohort of pediatric HTP. HTP (n = 7) exercised on a semi-recumbent ergometer to volitional fatigue. Echocardiography-Doppler measurements, HR, and blood pressure were taken at rest and during staged exercise. Results were compared with healthy CON (n = 12). HTP did significantly less work during exercise (940 vs. 1218 J/kg, p < 0.03). Their SVI (33 vs. 49 mL/m(2), p < 0.003), CI (5.16 vs. 9.25 L/min/m(2), p < 0.0005), and HR (162 vs. 185 bpm, p < 0.02) were lower at peak exercise. HTP had a lower SF at peak exercise (48% vs. 52%, p < 0.03) and an abnormal relationship between the MVCFc and ?PS. During follow-up, hemodynamics and left ventricular function remained relatively constant in HTP. HTP are able to exercise safely; however, their exercise tolerance is reduced, and hemodynamics and contractility are diminished. Over time, their hemodynamics and left ventricular function have remained relatively constant.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1399-3046
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2011 John Wiley & Sons A/S.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
265-71
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| pubmed:meshHeading |
pubmed-meshheading:21492351-Adolescent,
pubmed-meshheading:21492351-Adult,
pubmed-meshheading:21492351-Blood Pressure,
pubmed-meshheading:21492351-Child,
pubmed-meshheading:21492351-Echocardiography,
pubmed-meshheading:21492351-Echocardiography, Stress,
pubmed-meshheading:21492351-Exercise,
pubmed-meshheading:21492351-Exercise Test,
pubmed-meshheading:21492351-Exercise Tolerance,
pubmed-meshheading:21492351-Female,
pubmed-meshheading:21492351-Heart Diseases,
pubmed-meshheading:21492351-Heart Transplantation,
pubmed-meshheading:21492351-Hemodynamics,
pubmed-meshheading:21492351-Humans,
pubmed-meshheading:21492351-Immunosuppressive Agents,
pubmed-meshheading:21492351-Male,
pubmed-meshheading:21492351-Pediatrics,
pubmed-meshheading:21492351-Treatment Outcome,
pubmed-meshheading:21492351-Ultrasonography, Doppler,
pubmed-meshheading:21492351-Ventricular Function, Left
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| pubmed:year |
2011
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| pubmed:articleTitle |
Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography.
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| pubmed:affiliation |
Department of Pediatrics, BC Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
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| pubmed:publicationType |
Journal Article
|