Linked Life Data

21490214

Source:http://linkedlifedata.com/resource/pubmed/id/21490214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2011-4-14
pubmed:abstractText
Ingestion of dietary fat stimulates production of the small-intestinal satiety factors oleoylethanolamide (OEA) and N-palmitoyl-phosphatidylethanolamine (NPPE), which reduce food intake through a combination of local (OEA) and systemic (NPPE) actions. Previous studies have shown that sympathetic innervation of the gut is necessary for duodenal infusions of fat to induce satiety, suggesting that sympathetic activity may engage small-intestinal satiety signals such as OEA and NPPE. In the present study, we show that surgical resection of the sympathetic celiac-superior mesenteric ganglion complex, which sends projections to the upper gut, abolishes feeding-induced OEA production in rat small-intestinal cells. These effects are accounted for by suppression of OEA biosynthesis, and are mimicked by administration of the selective ?2-adrenergic receptor antagonist ICI-118,551. We further show that sympathetic ganglionectomy or pharmacological blockade of ?2-adrenergic receptors prevents NPPE release into the circulation. In addition, sympathetic ganglionectomy increases meal frequency and lowers satiety ratio, and these effects are corrected by pharmacological administration of OEA. The results suggest that sympathetic activity controls fat-induced satiety by enabling the coordinated production of local (OEA) and systemic (NPPE) satiety signals in the small intestine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5730-6
pubmed:dateRevised
2011-10-13
pubmed:meshHeading
pubmed-meshheading:21490214-Adrenergic Antagonists, pubmed-meshheading:21490214-Adrenergic beta-Agonists, pubmed-meshheading:21490214-Amidohydrolases, pubmed-meshheading:21490214-Animals, pubmed-meshheading:21490214-Chromatography, High Pressure Liquid, pubmed-meshheading:21490214-Dietary Fats, pubmed-meshheading:21490214-Eating, pubmed-meshheading:21490214-Feeding Behavior, pubmed-meshheading:21490214-Food, pubmed-meshheading:21490214-Ganglia, Sympathetic, pubmed-meshheading:21490214-Ganglionectomy, pubmed-meshheading:21490214-Intestine, Small, pubmed-meshheading:21490214-Male, pubmed-meshheading:21490214-Oleic Acids, pubmed-meshheading:21490214-Phospholipase D, pubmed-meshheading:21490214-Propanolamines, pubmed-meshheading:21490214-Rats, pubmed-meshheading:21490214-Rats, Sprague-Dawley, pubmed-meshheading:21490214-Receptors, Adrenergic, beta-2, pubmed-meshheading:21490214-Satiety Response, pubmed-meshheading:21490214-Signal Transduction, pubmed-meshheading:21490214-Sympathectomy, pubmed-meshheading:21490214-Sympathetic Nervous System
pubmed:year
2011
pubmed:articleTitle
Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine.
pubmed:affiliation
Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, California 92697-4625, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural