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rdf:type |
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lifeskim:mentions |
umls-concept:C0029347,
umls-concept:C0032285,
umls-concept:C0035647,
umls-concept:C0035820,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205178,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2350466,
umls-concept:C2587213,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
10
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pubmed:dateCreated |
2011-5-4
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pubmed:abstractText |
Influenza A virus (IAV) infection results in a highly contagious respiratory illness leading to substantial morbidity and occasionally death. In this report, we assessed the in vivo physiological contribution of invariant NKT (iNKT) lymphocytes, a subset of lipid-reactive ?? T lymphocytes, on the host response and viral pathogenesis using a virulent, mouse-adapted, IAV H3N2 strain. Upon infection with a lethal dose of IAV, iNKT cells become activated in the lungs and bronchoalveolar space to become rapidly anergic to further restimulation. Relative to wild-type animals, C57BL/6 mice deficient in iNKT cells (J?18(-/-) mice) developed a more severe bronchopneumonia and had an accelerated fatal outcome, a phenomenon reversed by the adoptive transfer of NKT cells prior to infection. The enhanced pathology in J?18(-/-) animals was not associated with either reduced or delayed viral clearance in the lungs or with a defective local NK cell response. In marked contrast, J?18(-/-) mice displayed a dramatically reduced IAV-specific CD8(+) T cell response in the lungs and in lung-draining mediastinal lymph nodes. We further show that this defective CD8(+) T cell response correlates with an altered accumulation and maturation of pulmonary CD103(+), but not CD11b(high), dendritic cells in the mediastinal lymph nodes. Taken together, these findings point to a role for iNKT cells in the control of pneumonia as well as in the development of the CD8(+) T cell response during the early stage of acute IAV H3N2 infection.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1550-6606
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pubmed:author |
pubmed-author:Barba-SpaethGiovannaG,
pubmed-author:Barba-SpeathGiovannaG,
pubmed-author:BialeckiEmilieE,
pubmed-author:BlancFanyF,
pubmed-author:FaveeuwChristelleC,
pubmed-author:FontaineJosetteJ,
pubmed-author:HuerreMichel-RenéMR,
pubmed-author:IvanovStoyanS,
pubmed-author:PagetChristopheC,
pubmed-author:PichavantMurielM,
pubmed-author:PothlichetJulienJ,
pubmed-author:RennesonJoelleJ,
pubmed-author:Si-TaharMustaphaM,
pubmed-author:TrotteinFrançoisF,
pubmed-author:VendevilleCatherineC
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5590-602
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pubmed:dateRevised |
2011-9-14
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pubmed:meshHeading |
pubmed-meshheading:21490153-Adoptive Transfer,
pubmed-meshheading:21490153-Animals,
pubmed-meshheading:21490153-Antigens, CD,
pubmed-meshheading:21490153-Antigens, CD11b,
pubmed-meshheading:21490153-Bronchopneumonia,
pubmed-meshheading:21490153-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21490153-Dendritic Cells,
pubmed-meshheading:21490153-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21490153-Inflammation,
pubmed-meshheading:21490153-Influenza A Virus, H3N2 Subtype,
pubmed-meshheading:21490153-Integrin alpha Chains,
pubmed-meshheading:21490153-Lung,
pubmed-meshheading:21490153-Lymphocyte Activation,
pubmed-meshheading:21490153-Mice,
pubmed-meshheading:21490153-Mice, Inbred C57BL,
pubmed-meshheading:21490153-Natural Killer T-Cells,
pubmed-meshheading:21490153-Orthomyxoviridae Infections,
pubmed-meshheading:21490153-Pneumonia, Viral,
pubmed-meshheading:21490153-Polymerase Chain Reaction,
pubmed-meshheading:21490153-Viral Load
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pubmed:year |
2011
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pubmed:articleTitle |
Potential role of invariant NKT cells in the control of pulmonary inflammation and CD8+ T cell response during acute influenza A virus H3N2 pneumonia.
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pubmed:affiliation |
Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille, F-59019 Lille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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