| pubmed-article:21489695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0376613 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0962546 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0040557 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C1519885 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:21489695 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:21489695 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:21489695 | pubmed:dateCreated | 2011-5-31 | lld:pubmed |
| pubmed-article:21489695 | pubmed:abstractText | A DNA vaccine (pVAX1-TgADF) encoding Toxoplasma gondii actin depolymerizing factor (ADF) gene was constructed and the immune response and protective efficacy of this vaccine against homologous challenge in BALB/c mice were evaluated. High titers of specific antibody and increases in the percentage of CD4(+) and CD8(+) T lymphocyte cells were observed from BALB/c mice vaccinated with pVAX1-TgADF (P<0.05), when PBS group was used as control. The survival time of BALB/c mice in pVAX1-TgADF group was longer than those in control groups. The numbers of brain cysts in the experimental BALB/c mice immunized with pVAX1-TgADF reduced significantly compared with those in PBS group (P<0.05), and the rate of reduction could reach to around 42.8%. These results suggested that the DNA vaccine pVAX1-TgADF could generate specific humoral and cellular immune responses, prolong survival times, and reduce brain cysts load against T. gondii infection in BALB/c mice. | lld:pubmed |
| pubmed-article:21489695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21489695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21489695 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21489695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21489695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21489695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21489695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21489695 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21489695 | pubmed:issn | 1873-2550 | lld:pubmed |
| pubmed-article:21489695 | pubmed:author | pubmed-author:WuLingL | lld:pubmed |
| pubmed-article:21489695 | pubmed:author | pubmed-author:LiJianhuaJ | lld:pubmed |
| pubmed-article:21489695 | pubmed:author | pubmed-author:ZhangXichenX | lld:pubmed |
| pubmed-article:21489695 | pubmed:author | pubmed-author:GongPengtaoP | lld:pubmed |
| pubmed-article:21489695 | pubmed:author | pubmed-author:ZhangGuocaiG | lld:pubmed |
| pubmed-article:21489695 | pubmed:author | pubmed-author:HuangXiangshe... | lld:pubmed |
| pubmed-article:21489695 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21489695 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21489695 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:21489695 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:21489695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21489695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21489695 | pubmed:pagination | 1-6 | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
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| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:meshHeading | pubmed-meshheading:21489695... | lld:pubmed |
| pubmed-article:21489695 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21489695 | pubmed:articleTitle | Immune response and protective efficacy against homologous challenge in BALB/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene. | lld:pubmed |
| pubmed-article:21489695 | pubmed:affiliation | College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin 130062, China. Jianhuali7207@163.com | lld:pubmed |
| pubmed-article:21489695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21489695 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
