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pubmed-article:21482963pubmed:abstractTextThe reverse rate dependence (RRD) of actions of I(Kr)-blocking drugs to increase the action potential duration (APD) and beat-to-beat variability of repolarization (BVR) of APD is proarrhythmic. We determined whether inhibition of endogenous, physiological late Na(+) current (late I(Na)) attenuates the RRD and proarrhythmic effect of I(Kr) inhibition.lld:pubmed
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pubmed-article:21482963pubmed:articleTitleLate sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.lld:pubmed
pubmed-article:21482963pubmed:affiliationDepartment of Biology, Gilead Sciences, 1651 Page Mill Road, Palo Alto, CA 94304, USA. lin971@yahoo.comlld:pubmed
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pubmed-article:21482963pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed