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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2011-4-26
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pubmed:abstractText |
The reverse rate dependence (RRD) of actions of I(Kr)-blocking drugs to increase the action potential duration (APD) and beat-to-beat variability of repolarization (BVR) of APD is proarrhythmic. We determined whether inhibition of endogenous, physiological late Na(+) current (late I(Na)) attenuates the RRD and proarrhythmic effect of I(Kr) inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetanilides,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Arrhythmia Agents,
http://linkedlifedata.com/resource/pubmed/chemical/E 4031,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/ranolazine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
26
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1713-20
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pubmed:meshHeading |
pubmed-meshheading:21482963-Acetanilides,
pubmed-meshheading:21482963-Action Potentials,
pubmed-meshheading:21482963-Animals,
pubmed-meshheading:21482963-Anti-Arrhythmia Agents,
pubmed-meshheading:21482963-Bradycardia,
pubmed-meshheading:21482963-Disease Models, Animal,
pubmed-meshheading:21482963-Enzyme Inhibitors,
pubmed-meshheading:21482963-Female,
pubmed-meshheading:21482963-Heart Rate,
pubmed-meshheading:21482963-Long QT Syndrome,
pubmed-meshheading:21482963-Models, Cardiovascular,
pubmed-meshheading:21482963-Myocardial Contraction,
pubmed-meshheading:21482963-Myocytes, Cardiac,
pubmed-meshheading:21482963-Patch-Clamp Techniques,
pubmed-meshheading:21482963-Piperazines,
pubmed-meshheading:21482963-Piperidines,
pubmed-meshheading:21482963-Pyridines,
pubmed-meshheading:21482963-Rabbits,
pubmed-meshheading:21482963-Sodium,
pubmed-meshheading:21482963-Sodium Channel Blockers,
pubmed-meshheading:21482963-Sodium Channels,
pubmed-meshheading:21482963-Tetrodotoxin,
pubmed-meshheading:21482963-Torsades de Pointes
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pubmed:year |
2011
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pubmed:articleTitle |
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.
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pubmed:affiliation |
Department of Biology, Gilead Sciences, 1651 Page Mill Road, Palo Alto, CA 94304, USA. lin971@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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