Source:http://linkedlifedata.com/resource/pubmed/id/21481713
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-4-12
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| pubmed:databankReference | |
| pubmed:abstractText |
The purpose of this study was to correlate biomarkers of metabolic syndrome (MetS), with markers of inflammation and macronutrient intake in 89 women (25-72 years) with MetS. We hypothesized that waist circumference (WC) would have the stronger correlations with inflammatory parameters and would correlate with carbohydrate intake. Values for WC (108.7 ± 11.1 cm) and plasma triglycerides (202.7 ± 52.1 mg/dL) were elevated, whereas plasma glucose levels varied from 66 to 179 mg/dL, with 42% of women having insulin resistance. Plasma levels of interleukin 6 (0.2-15.9 mg/L), tumor necrosis factor ? (1.47-12.3 mg/L), and high-sensitivity C-reactive protein (0.06-3.08 mg/dL) varied widely, with most women being above values considered normal. Subjects had high intake of total sugar (92.3 ± 56.4 g/d), high glycemic index (59.8 ± 6.5), and glycemic load (127.2 ± 56.1), whereas dietary fiber (17.1 ± 9.1 g/d) was below recommended intake. Waist circumference was positively correlated with insulin (r = 0.275, P < .01) and with the inflammatory markers interleukin 6 (r = 0.307, P < .01) and tumor necrosis factor ? (r = 0.228, P < .05) and negatively correlated with plasma adiponectin (r = -0.309, P < .0001). In addition, WC was positively correlated with total carbohydrate, added sugar, and glycemic load (P < .05) but not with fat or protein. These results are consistent with central obesity being a key marker of the inflammatory state, and they also suggest that carbohydrates, particularly those that are digested rapidly, contribute to increased risk of central obesity and development of MetS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1879-0739
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| pubmed:author |
pubmed-author:AckermannDanielaD,
pubmed-author:BaronaJacquelineJ,
pubmed-author:CalleMariana CMC,
pubmed-author:FernandezMaria LuzML,
pubmed-author:JonesJenniferJ,
pubmed-author:KalynychColleenC,
pubmed-author:KimJung EunJE,
pubmed-author:LaPiaBrandenB,
pubmed-author:LermanRobert HRH,
pubmed-author:McIntoshMarkM,
pubmed-author:NajmWadieW,
pubmed-author:VolekJeff SJS
|
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
31
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
197-204
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:21481713-Adiponectin,
pubmed-meshheading:21481713-Adult,
pubmed-meshheading:21481713-Aged,
pubmed-meshheading:21481713-Biological Markers,
pubmed-meshheading:21481713-Blood Glucose,
pubmed-meshheading:21481713-Body Mass Index,
pubmed-meshheading:21481713-C-Reactive Protein,
pubmed-meshheading:21481713-Cross-Sectional Studies,
pubmed-meshheading:21481713-Diet,
pubmed-meshheading:21481713-Dietary Carbohydrates,
pubmed-meshheading:21481713-Female,
pubmed-meshheading:21481713-Glycemic Index,
pubmed-meshheading:21481713-Humans,
pubmed-meshheading:21481713-Inflammation,
pubmed-meshheading:21481713-Insulin,
pubmed-meshheading:21481713-Insulin Resistance,
pubmed-meshheading:21481713-Interleukin-6,
pubmed-meshheading:21481713-Metabolic Syndrome X,
pubmed-meshheading:21481713-Middle Aged,
pubmed-meshheading:21481713-Waist Circumference
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| pubmed:year |
2011
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| pubmed:articleTitle |
Waist circumference is positively correlated with markers of inflammation and negatively with adiponectin in women with metabolic syndrome.
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| pubmed:affiliation |
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|