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pubmed-article:21480817pubmed:abstractTextTacrolimus (Tac) is an immunosuppressive drug used to prevent post-transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose and prevent toxicity or rejection. Tac is metabolized by cytochrome-P450 (CYP) enzymes, and variation at the CYP and other drug metabolizing enzymes could influence Tac bio-availability and dose requirements. Our aim was to define the effect of DNA variants at 16 drug metabolising enzymes on Tac dose in patients with kidney transplants.lld:pubmed
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pubmed-article:21480817pubmed:dateRevised2011-8-5lld:pubmed
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pubmed-article:21480817pubmed:articleTitlePharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes.lld:pubmed
pubmed-article:21480817pubmed:affiliationGenética Molecular, Hospital Universitario Central de Asturias, Oviedo, Spain.lld:pubmed
pubmed-article:21480817pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21480817pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed