rdf:type |
|
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0014442,
umls-concept:C0022671,
umls-concept:C0031325,
umls-concept:C0085149,
umls-concept:C0679058,
umls-concept:C0936012,
umls-concept:C1337112,
umls-concept:C1547699,
umls-concept:C1882417,
umls-concept:C2700640
|
pubmed:issue |
5
|
pubmed:dateCreated |
2011-4-12
|
pubmed:abstractText |
Tacrolimus (Tac) is an immunosuppressive drug used to prevent post-transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose and prevent toxicity or rejection. Tac is metabolized by cytochrome-P450 (CYP) enzymes, and variation at the CYP and other drug metabolizing enzymes could influence Tac bio-availability and dose requirements. Our aim was to define the effect of DNA variants at 16 drug metabolising enzymes on Tac dose in patients with kidney transplants.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1434-6621
|
pubmed:author |
pubmed-author:AlvarezVictoriaV,
pubmed-author:AlvarezcaVictoriaV,
pubmed-author:AriasManuelM,
pubmed-author:CampistolJosep MJM,
pubmed-author:CotoEliecerE,
pubmed-author:Díaz-CorteCarmenC,
pubmed-author:DíazJuan MJM,
pubmed-author:GarciáEliecer CotoEC,
pubmed-author:López-LarreaCarlosC,
pubmed-author:OrtegaFranciscoF,
pubmed-author:REDINREN Pharmacogenetics group,
pubmed-author:SelgasRafaelR,
pubmed-author:TaviraBeatrizB,
pubmed-author:TorresArmandoA
|
pubmed:issnType |
Print
|
pubmed:volume |
49
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
825-33
|
pubmed:dateRevised |
2011-8-5
|
pubmed:meshHeading |
pubmed-meshheading:21480817-Adolescent,
pubmed-meshheading:21480817-Adult,
pubmed-meshheading:21480817-Aged,
pubmed-meshheading:21480817-DNA,
pubmed-meshheading:21480817-Endpoint Determination,
pubmed-meshheading:21480817-Enzymes,
pubmed-meshheading:21480817-Female,
pubmed-meshheading:21480817-Genotype,
pubmed-meshheading:21480817-Humans,
pubmed-meshheading:21480817-Individualized Medicine,
pubmed-meshheading:21480817-Kidney Transplantation,
pubmed-meshheading:21480817-Male,
pubmed-meshheading:21480817-Middle Aged,
pubmed-meshheading:21480817-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21480817-Polymorphism, Genetic,
pubmed-meshheading:21480817-Reproducibility of Results,
pubmed-meshheading:21480817-Tacrolimus,
pubmed-meshheading:21480817-Young Adult
|
pubmed:year |
2011
|
pubmed:articleTitle |
Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes.
|
pubmed:affiliation |
Genética Molecular, Hospital Universitario Central de Asturias, Oviedo, Spain.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|