Linked Life Data

2147875

Source:http://linkedlifedata.com/resource/pubmed/id/2147875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1991-1-31
pubmed:abstractText
Previous work from our laboratory has shown that (i) regular endurance exercise lowers blood pressure (BP), and (ii) acute exercise increases circulating levels of atrial natriuretic peptide (ANP). We hypothesised that increased ANP release may contribute to the antihypertensive effect of regular exercise. Using arterial and selective venous (coronary sinus and renal vein) catheterization and sampling, we measured cardiac secretion and renal clearance of ANP at rest in 7 normal healthy males (mean age 36 years), before and after 4 weeks of training. Body weight and haematocrit remained unchanged. Systolic BP fell by 10 mmHg with training (p = 0.008), diastolic BP fell by 6 mmHg (p = 0.006) and heart rate decreased by 9 beats/minute (p = 0.002), but central venous pressure remained unchanged. Arterial, coronary sinus and renal vein ANP concentrations did not change with training. There was no significant rise in cardiac secretion of ANP with training (sedentary: 42.6 +/- 13.2 ng/ml, trained: 47.4 +/- 17.9 ng/ml, p n.s.). Renal extraction of ANP was 72 +/- 4% before training, and unchanged (66 +/- 5%) after the exercise period. Renal clearance of ANP was also unaltered by training (514.2 +/- 48.4 ml/min before, and 508.9 +/- 74.8 ml/min after training, p n.s.). We conclude that as ANP release is not increased by training, the peptide does not account for the anti-hypertensive effect of endurance exercise. Other humoral and/or neural mechanisms possibly mediate the beneficial haemodynamic effects of training.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0730-0077
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1223-35
pubmed:dateRevised
2008-2-12
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of endurance exercise on cardiac secretion and renal clearance of atrial natriuretic peptide in normal humans.
pubmed:affiliation
Alfred and Baker Medical Unit, Alfred Hospital, Prahran, Victoria, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't