Linked Life Data

21476910

Source:http://linkedlifedata.com/resource/pubmed/id/21476910

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-4-11
pubmed:abstractText
Nonalcoholic fatty liver disease is one of the most prevalent liver diseases worldwide. Its etiology is multifactorial and genetic factors most likely play a role. Genome-wide association studies have identified the first candidate genes, including patatin-like phospholipase 3, a lipase that is involved in triglyceride metabolism. Several other genetic variants have been identified, although with less convincing evidence. These genetic variants encode for molecules regulating insulin signalling, lipid metabolism, inflammation or fibrogenesis. Whereas the biological functions of TNF-? have been demonstrated to play an important role in the regulation of insulin resistance, liver inflammation and lipid accumulation, further genetic studies are needed to clarify whether and which TNF-? genetic variants predispose to the development of nonalcoholic steatohepatitis, the inflammatory component of nonalcoholic fatty liver disease.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Apr
pubmed:issn
1747-4132
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-8
pubmed:year
2011
pubmed:articleTitle
Relevance of TNF-? gene polymorphisms in nonalcoholic fatty liver disease.
pubmed:affiliation
Christian Doppler Research Laboratory for Gut Inflammation, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
pubmed:publicationType
Journal Article, Comment, Research Support, Non-U.S. Gov't