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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-9
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pubmed:abstractText |
We determined the contribution to insulin resistance of the PH domain leucine-rich repeat protein phosphatase (PHLPP), which dephosphorylates Akt at Ser473, inhibiting its activity. We measured the abundance of PHLPP in fat and skeletal muscle from obese participants. To study the effect of PHLPP on insulin signalling, PHLPP (also known as PHLPP1) was overexpressed in HepG2 and L6 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1432-0428
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pubmed:author |
pubmed-author:AndreozziFF,
pubmed-author:BeguinotFF,
pubmed-author:FolliFF,
pubmed-author:GrecoAA,
pubmed-author:HribalM LML,
pubmed-author:IadiciccoCC,
pubmed-author:ManningG KGK,
pubmed-author:MieliGG,
pubmed-author:PontiroliA EAE,
pubmed-author:ProcopioCC,
pubmed-author:RacitiG AGA,
pubmed-author:SestoMM
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1879-87
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pubmed:meshHeading |
pubmed-meshheading:21461637-Adolescent,
pubmed-meshheading:21461637-Adult,
pubmed-meshheading:21461637-Aged,
pubmed-meshheading:21461637-Animals,
pubmed-meshheading:21461637-Blotting, Western,
pubmed-meshheading:21461637-Cell Line,
pubmed-meshheading:21461637-Female,
pubmed-meshheading:21461637-Hep G2 Cells,
pubmed-meshheading:21461637-Humans,
pubmed-meshheading:21461637-Insulin Resistance,
pubmed-meshheading:21461637-Male,
pubmed-meshheading:21461637-Middle Aged,
pubmed-meshheading:21461637-Nuclear Proteins,
pubmed-meshheading:21461637-Obesity,
pubmed-meshheading:21461637-Phosphoprotein Phosphatases,
pubmed-meshheading:21461637-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21461637-Rats,
pubmed-meshheading:21461637-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.
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pubmed:affiliation |
Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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