| pubmed-article:21459583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21459583 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:21459583 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:21459583 | lifeskim:mentions | umls-concept:C0052495 | lld:lifeskim |
| pubmed-article:21459583 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21459583 | pubmed:dateCreated | 2011-4-12 | lld:pubmed |
| pubmed-article:21459583 | pubmed:abstractText | New multi-valent, carbohydrate ligands that contain terminal N-acetylgalactosamine (GalNAc) or lactose (Lac) were prepared using a nitrilotriacetic acid (NTA) derivative of L-lysine as scaffold. Tri-valent structures were prepared by attaching an ?-amino glycoside of GalNAc or Lac to each of the three carboxyl groups of N(?)-protected N(?)-dicarboxymethyl-L-lysine. In addition, a hexa-valent lactoside was synthesized by attaching N(?)-deprotected trivalent lactoside to each of the carboxyl group of N(?)-(trifluoroacetamido)hexanoyl L-aspartic acid. Tri-valent GalNAc glycosides and the hexa-valent lactoside had high affinity (dissociation constants approaching nM) for rat hepatocytes. The hexa-valent lactoside, after de-N(?)-protection, was modified with a chelator, diethylenetriaminepentaacetic acid (DTPA), through which a fluorescent or radioactive tag, such as europium or indium, can be firmly attached. Intravenous infusion of (111)Indium-tagged hexa-valent lactoside to rats and mice resulted in nearly exclusive accumulation of radioactivity in the liver. | lld:pubmed |
| pubmed-article:21459583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21459583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21459583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21459583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21459583 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21459583 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:21459583 | pubmed:author | pubmed-author:LeeReiko TRT | lld:pubmed |
| pubmed-article:21459583 | pubmed:author | pubmed-author:LeeYuan CYC | lld:pubmed |
| pubmed-article:21459583 | pubmed:author | pubmed-author:WangMei-HuiMH | lld:pubmed |
| pubmed-article:21459583 | pubmed:author | pubmed-author:LinWuu-JyhWJ | lld:pubmed |
| pubmed-article:21459583 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21459583 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21459583 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21459583 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:21459583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21459583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21459583 | pubmed:pagination | 2494-500 | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:meshHeading | pubmed-meshheading:21459583... | lld:pubmed |
| pubmed-article:21459583 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21459583 | pubmed:articleTitle | New and more efficient multivalent glyco-ligands for asialoglycoprotein receptor of mammalian hepatocytes. | lld:pubmed |
| pubmed-article:21459583 | pubmed:affiliation | Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. | lld:pubmed |
| pubmed-article:21459583 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21459583 | lld:chembl |
