Linked Life Data

21459583

Source:http://linkedlifedata.com/resource/pubmed/id/21459583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-4-12
pubmed:abstractText
New multi-valent, carbohydrate ligands that contain terminal N-acetylgalactosamine (GalNAc) or lactose (Lac) were prepared using a nitrilotriacetic acid (NTA) derivative of L-lysine as scaffold. Tri-valent structures were prepared by attaching an ?-amino glycoside of GalNAc or Lac to each of the three carboxyl groups of N(?)-protected N(?)-dicarboxymethyl-L-lysine. In addition, a hexa-valent lactoside was synthesized by attaching N(?)-deprotected trivalent lactoside to each of the carboxyl group of N(?)-(trifluoroacetamido)hexanoyl L-aspartic acid. Tri-valent GalNAc glycosides and the hexa-valent lactoside had high affinity (dissociation constants approaching nM) for rat hepatocytes. The hexa-valent lactoside, after de-N(?)-protection, was modified with a chelator, diethylenetriaminepentaacetic acid (DTPA), through which a fluorescent or radioactive tag, such as europium or indium, can be firmly attached. Intravenous infusion of (111)Indium-tagged hexa-valent lactoside to rats and mice resulted in nearly exclusive accumulation of radioactivity in the liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-3391
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2494-500
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
New and more efficient multivalent glyco-ligands for asialoglycoprotein receptor of mammalian hepatocytes.
pubmed:affiliation
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
pubmed:publicationType
Journal Article