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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-4-4
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pubmed:abstractText |
In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial artificial chromosome-mediated transgenic HD (BACHD) mice developed impaired glucose metabolism and pronounced insulin and leptin resistance. Selective hypothalamic expression of a short fragment of mutant huntingtin using adeno-associated viral vectors was sufficient to recapitulate these metabolic disturbances. Finally, selective hypothalamic inactivation of the mutant gene prevented the development of the metabolic phenotype in BACHD mice. Our findings establish a causal link between mutant huntingtin expression in the hypothalamus and metabolic dysfunction, and indicate that metabolic parameters are powerful readouts to assess therapies aimed at correcting dysfunction in HD by silencing huntingtin expression in the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hap1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Huntington protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/orexins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1932-7420
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
428-39
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pubmed:meshHeading |
pubmed-meshheading:21459327-Adenoviridae,
pubmed-meshheading:21459327-Animals,
pubmed-meshheading:21459327-Female,
pubmed-meshheading:21459327-Gene Expression Regulation,
pubmed-meshheading:21459327-Huntington Disease,
pubmed-meshheading:21459327-Hypothalamus,
pubmed-meshheading:21459327-Insulin Resistance,
pubmed-meshheading:21459327-Insulin-Like Growth Factor I,
pubmed-meshheading:21459327-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:21459327-Leptin,
pubmed-meshheading:21459327-Male,
pubmed-meshheading:21459327-Mice,
pubmed-meshheading:21459327-Mice, Transgenic,
pubmed-meshheading:21459327-Mutation,
pubmed-meshheading:21459327-Nerve Tissue Proteins,
pubmed-meshheading:21459327-Neuropeptides,
pubmed-meshheading:21459327-Nuclear Proteins,
pubmed-meshheading:21459327-Phenotype
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pubmed:year |
2011
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pubmed:articleTitle |
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
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pubmed:affiliation |
Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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