| pubmed-article:2143752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2143752 | lifeskim:mentions | umls-concept:C0035495 | lld:lifeskim |
| pubmed-article:2143752 | lifeskim:mentions | umls-concept:C0038856 | lld:lifeskim |
| pubmed-article:2143752 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:2143752 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2143752 | lifeskim:mentions | umls-concept:C1518413 | lld:lifeskim |
| pubmed-article:2143752 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2143752 | pubmed:dateCreated | 1990-9-27 | lld:pubmed |
| pubmed-article:2143752 | pubmed:abstractText | Antibody responses of mice immunized with type III pneumococcal polysaccharide were examined with and without treatment with nontoxic lipopolysaccharide from Rhodopseudomonas sphaeroides (Rs-LPS). The results obtained were similar to those described previously for mice treated with monophosphoryl lipid A (MPL) except that lower amounts of Rs-LPS were needed. Both were without effect when given at the time of immunization with type III pneumococcal polysaccharide but elicited significant enhancement when given 2 to 3 days later. Such enhancement was T cell dependent and not due to polyclonal activation of immunoglobulin M synthesis by B cells. Treatment with either Rs-LPS or MPL abolished the expression but not induction of low-dose paralysis, a form of immunological unresponsiveness known to be mediated by suppressor T cells (Ts). The in vitro treatment of cell suspensions containing Ts with extremely small amounts of Rs-LPS or MPI completely eliminated the capacity of such cells to transfer suppression to other mice. These findings indicate that the immunomodulatory effects of both MPL and Rs-LPS are mainly the result of eliminating the inhibitors effects of Ts; this permits the positive effects of amplifier T cells to be more fully expressed, thereby resulting in an increased antibody response. The significance of these and other findings to the use of Rs-LPS as a pharmacotherapeutic agent for gram-negative bacterial sepsis is discussed. | lld:pubmed |
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| pubmed-article:2143752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2143752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2143752 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2143752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2143752 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2143752 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:BakerP JPJ | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:StashakP WPW | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:TakayamaKK | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:QureshiNN | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:TaylorC ECE | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:HasløvKK | lld:pubmed |
| pubmed-article:2143752 | pubmed:author | pubmed-author:FauntleroyM... | lld:pubmed |
| pubmed-article:2143752 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2143752 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2143752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2143752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2143752 | pubmed:pagination | 2862-8 | lld:pubmed |
| pubmed-article:2143752 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2143752 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2143752 | pubmed:articleTitle | Inactivation of suppressor T cell activity by the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides. | lld:pubmed |
| pubmed-article:2143752 | pubmed:affiliation | Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852. | lld:pubmed |
| pubmed-article:2143752 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2143752 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2143752 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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