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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1990-9-27
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pubmed:abstractText |
Antibody responses of mice immunized with type III pneumococcal polysaccharide were examined with and without treatment with nontoxic lipopolysaccharide from Rhodopseudomonas sphaeroides (Rs-LPS). The results obtained were similar to those described previously for mice treated with monophosphoryl lipid A (MPL) except that lower amounts of Rs-LPS were needed. Both were without effect when given at the time of immunization with type III pneumococcal polysaccharide but elicited significant enhancement when given 2 to 3 days later. Such enhancement was T cell dependent and not due to polyclonal activation of immunoglobulin M synthesis by B cells. Treatment with either Rs-LPS or MPL abolished the expression but not induction of low-dose paralysis, a form of immunological unresponsiveness known to be mediated by suppressor T cells (Ts). The in vitro treatment of cell suspensions containing Ts with extremely small amounts of Rs-LPS or MPI completely eliminated the capacity of such cells to transfer suppression to other mice. These findings indicate that the immunomodulatory effects of both MPL and Rs-LPS are mainly the result of eliminating the inhibitors effects of Ts; this permits the positive effects of amplifier T cells to be more fully expressed, thereby resulting in an increased antibody response. The significance of these and other findings to the use of Rs-LPS as a pharmacotherapeutic agent for gram-negative bacterial sepsis is discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-14193155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-1968433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-2784418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-2904409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-2943420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-2965680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-2972626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3010124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3136169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3258599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3543677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3555304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3596805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3764421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3801029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3819645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-3895437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4145387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4149590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4388600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4391281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4396488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4396489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4398381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-4857626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-5804498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6173416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6193230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6333338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6355095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6355099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6382555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6602801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6707694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6749846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-6973183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143752-789096
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2862-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2143752-Animals,
pubmed-meshheading:2143752-Antibodies, Bacterial,
pubmed-meshheading:2143752-B-Lymphocytes,
pubmed-meshheading:2143752-Female,
pubmed-meshheading:2143752-Immunoglobulin M,
pubmed-meshheading:2143752-Lipid A,
pubmed-meshheading:2143752-Lymphocyte Activation,
pubmed-meshheading:2143752-Mice,
pubmed-meshheading:2143752-Mice, Nude,
pubmed-meshheading:2143752-Polysaccharides, Bacterial,
pubmed-meshheading:2143752-Rhodobacter sphaeroides,
pubmed-meshheading:2143752-T-Lymphocytes, Regulatory
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pubmed:year |
1990
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pubmed:articleTitle |
Inactivation of suppressor T cell activity by the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides.
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pubmed:affiliation |
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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