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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
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pubmed:dateCreated |
2011-4-12
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pubmed:abstractText |
A series of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles 14a-e, 15a-e, 17a-c, and 18a-d have been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 6-quinolinyl pyrazole analogue 14b inhibited ALK5 phosphorylation with IC(50) value of 0.022 ?M and showed 84% inhibition at 0.1 ?M in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
|
pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
19
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2633-40
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|
pubmed:meshHeading |
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-? type 1 receptor kinase inhibitors.
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|
pubmed:affiliation |
College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
