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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6285
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pubmed:dateCreated |
1990-9-17
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pubmed:databankReference |
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pubmed:abstractText |
The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
346
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
623-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2143562-Adenosine Triphosphatases,
pubmed-meshheading:2143562-Adenosine Triphosphate,
pubmed-meshheading:2143562-Amino Acid Sequence,
pubmed-meshheading:2143562-Animals,
pubmed-meshheading:2143562-Binding Sites,
pubmed-meshheading:2143562-Cattle,
pubmed-meshheading:2143562-Chemistry, Physical,
pubmed-meshheading:2143562-Computer Simulation,
pubmed-meshheading:2143562-Crystallization,
pubmed-meshheading:2143562-Heat-Shock Proteins,
pubmed-meshheading:2143562-Hexokinase,
pubmed-meshheading:2143562-Macromolecular Substances,
pubmed-meshheading:2143562-Models, Molecular,
pubmed-meshheading:2143562-Molecular Sequence Data,
pubmed-meshheading:2143562-Molecular Structure,
pubmed-meshheading:2143562-Molecular Weight,
pubmed-meshheading:2143562-Osmolar Concentration,
pubmed-meshheading:2143562-Peptide Fragments,
pubmed-meshheading:2143562-Physicochemical Phenomena,
pubmed-meshheading:2143562-Protein Conformation,
pubmed-meshheading:2143562-X-Ray Diffraction
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pubmed:year |
1990
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pubmed:articleTitle |
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein.
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pubmed:affiliation |
Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305-5400.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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