|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020852,
umls-concept:C0021745,
umls-concept:C0024432,
umls-concept:C0027950,
umls-concept:C0035696,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0597357,
umls-concept:C1414550,
umls-concept:C1414551,
umls-concept:C1414552,
umls-concept:C1510827,
umls-concept:C1552644,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2911684
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1990-9-10
|
|
pubmed:abstractText |
Immune interferon (IFN-gamma) induces in human neutrophils accumulation of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I, CD64) with a mechanism that is independent from de novo protein synthesis and from activation of the Na+/H+ antiporter. Monocyte-derived macrophages can also be induced to express high levels of Fc gamma R-I mRNA by IFN-gamma, without requirement of protein synthesis. Unlike what is observed in neutrophils, induction by IFN-gamma of macrophage Fc gamma R-I mRNA was significantly depressed by the Na+/H+ antiporter inhibitor amiloride. These results indicate that phagocytes' Fc gamma R-I mRNA induction by IFN-gamma is regulated by different mechanisms depending on the target cells.
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pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
31
|
|
pubmed:volume |
170
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
582-8
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:2143376-Amiloride,
pubmed-meshheading:2143376-Antigens, Differentiation,
pubmed-meshheading:2143376-Cells, Cultured,
pubmed-meshheading:2143376-Humans,
pubmed-meshheading:2143376-Interferon-gamma,
pubmed-meshheading:2143376-Macrophages,
pubmed-meshheading:2143376-Monocytes,
pubmed-meshheading:2143376-Neutrophils,
pubmed-meshheading:2143376-RNA, Messenger,
pubmed-meshheading:2143376-Receptors, Fc,
pubmed-meshheading:2143376-Receptors, IgG
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I or CD64).
|
|
pubmed:affiliation |
Institute of General Pathology, University of Verona, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
