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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-6-29
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pubmed:abstractText |
Ventricular myocytes isolated from hearts of streptozotocin (STZ)-diabetic rats exhibit increased spontaneous Ca(2+) release. Studies attribute this defect to an enhancement in activity of type 2 ryanodine receptor (RyR2). To date, underlying reasons for RyR2 dysregulation remain undefined. This study assesses whether the responsiveness of RyR2 following stimulation by intrinsic ligands is being altered during experimental type 1 diabetes (T1D).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
300-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21421556-Adenosine Triphosphate,
pubmed-meshheading:21421556-Analysis of Variance,
pubmed-meshheading:21421556-Animals,
pubmed-meshheading:21421556-Blotting, Western,
pubmed-meshheading:21421556-Calcium Signaling,
pubmed-meshheading:21421556-Cyclic ADP-Ribose,
pubmed-meshheading:21421556-Diabetes Mellitus, Experimental,
pubmed-meshheading:21421556-Diabetes Mellitus, Type 1,
pubmed-meshheading:21421556-Diabetic Cardiomyopathies,
pubmed-meshheading:21421556-Hypoglycemic Agents,
pubmed-meshheading:21421556-Insulin,
pubmed-meshheading:21421556-Ligands,
pubmed-meshheading:21421556-Magnesium,
pubmed-meshheading:21421556-Membrane Potentials,
pubmed-meshheading:21421556-Microscopy, Confocal,
pubmed-meshheading:21421556-Myocytes, Cardiac,
pubmed-meshheading:21421556-Phenotype,
pubmed-meshheading:21421556-Phosphorylation,
pubmed-meshheading:21421556-Rats,
pubmed-meshheading:21421556-Ryanodine,
pubmed-meshheading:21421556-Ryanodine Receptor Calcium Release Channel
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pubmed:year |
2011
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pubmed:articleTitle |
Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes.
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pubmed:affiliation |
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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