Linked Life Data

21419841

Source:http://linkedlifedata.com/resource/pubmed/id/21419841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-5-3
pubmed:abstractText
Curcumin exhibits various pharmacological actions including anti-inflammatory, anti-infectious, and anticancer actions. Furthermore, the supplements containing curcumin are supplied for persons consuming alcoholic beverage. A primary criterion for an ingredient ingested by general population is that it exerts no harmful effect. In this study, we examined the effect of curcumin on rat thymocytes to see if curcumin exerts cytotoxicity on normal cells. The incubation with 10 ?M curcumin for 24h increased the population of dead cells while it was not the case for 5 ?M or less. Curcumin at 5-10 ?M increased the populations of shrunken cells and the cells positive to annexin V, phenomena for early stage of apoptosis. However, the incubation with 10 ?M curcumin suppressed the increase in population of cells with hypodiploid DNA, a phenomenon for late stage of apoptosis. Thus, curcumin at 10 ?M may show both proapoptotic and antiapoptotic actions. The simultaneous incubation with 5 ?M, but not 3 ?M, curcumin and 0.5% ethanol increased the population of shrunken cells. It is likely that curcumin at 5 ?M or more exerts cytotoxic action on normal cells although many studies show some anticancer actions of curcumin at 10 ?M or more on cancer cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1879-3177
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
985-90
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Cytometric analysis on cytotoxicity of curcumin on rat thymocytes: Proapoptotic and antiapoptotic actions of curcumin.
pubmed:affiliation
Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan.
pubmed:publicationType
Journal Article