Linked Life Data

21413908

Source:http://linkedlifedata.com/resource/pubmed/id/21413908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-4-21
pubmed:abstractText
INTRODUCTION: Filamentous temperature sensitive mutant Z (FtsZ), an essential protein for bacterial cell division, has emerged as an attractive therapeutic target for the development of efficacious antibacterial agents active against drug-sensitive and drug-resistant bacterial strains. Recently, FtsZ has garnered special attention in the antibacterial research field, which is evident by the amount of research papers and patents disclosed in the public domain. Because of the significance of FtsZ as a highly promising target for the development of novel antibacterial agents, it is timely to review the patents on this subject so far published to date. AREAS COVERED: This review article covers the patent literature on FtsZ-targeting potential antibacterial agents up to November 2010, including their pharmacological findings. EXPERT OPINION: Since FtsZ is well preserved in various bacteria, the FtsZ-targeting agents would act as novel broad-spectrum antibacterial drugs in addition to their use against particular bacteria, especially drug-resistant strains. Based on the increasing interest and advancement in this field of research, it looks almost certain that a good number of clinical candidates targeting FtsZ will emerge in the near future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1744-7674
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
657-79
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Therapeutic potential of FtsZ inhibition: a patent perspective.
pubmed:affiliation
State University of New York at Stony Brook, Department of Chemistry, Stony Brook, NY 11794-3400, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural