21405945

Source:http://linkedlifedata.com/resource/pubmed/id/21405945

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0017636, umls-concept:C0076080, umls-concept:C0162638, umls-concept:C0205263, umls-concept:C1334505, umls-concept:C1710082
pubmed:issue	5
pubmed:dateCreated	2011-5-2
pubmed:abstractText	We investigated the molecular mechanisms underlying the cytotoxic effect of Temozolomide (TMZ) in both O(6)-methylguanine-DNA methyl transferase (MGMT) depleted as well as undepleted glioblastoma cell lines. Since TMZ is used in clinics in combination with radiotherapy, we also studied the effects of TMZ in combination with ionising radiation (IR).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8809243
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating, http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases, http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes, http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine, http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/MGMT protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta, http://linkedlifedata.com/resource/pubmed/chemical/temozolomide
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	1362-3095
pubmed:author	pubmed-author:BrunettiErcoleE, pubmed-author:BucciBarbaraB, pubmed-author:D'agnanoIgeaI, pubmed-author:De PaulaUgoU, pubmed-author:De SalvoMariaM, pubmed-author:GagliassiRaffaellaR, pubmed-author:MarcheseRodolfoR, pubmed-author:MarescaGiovannaG, pubmed-author:RazaGiorgio HGH, pubmed-author:StiglianoAntonioA
pubmed:issnType	Electronic
pubmed:volume	87
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	518-33
pubmed:dateRevised	2011-11-2
pubmed:meshHeading	pubmed-meshheading:21405945-Antineoplastic Agents, Alkylating, pubmed-meshheading:21405945-Apoptosis, pubmed-meshheading:21405945-Brain Neoplasms, pubmed-meshheading:21405945-Cell Cycle, pubmed-meshheading:21405945-Cell Line, Tumor, pubmed-meshheading:21405945-DNA Modification Methylases, pubmed-meshheading:21405945-DNA Repair Enzymes, pubmed-meshheading:21405945-Dacarbazine, pubmed-meshheading:21405945-Flow Cytometry, pubmed-meshheading:21405945-Glioblastoma, pubmed-meshheading:21405945-Glycogen Synthase Kinase 3, pubmed-meshheading:21405945-Humans, pubmed-meshheading:21405945-Proto-Oncogene Proteins c-akt, pubmed-meshheading:21405945-Proto-Oncogene Proteins c-myc, pubmed-meshheading:21405945-RNA, Small Interfering, pubmed-meshheading:21405945-Radiation, Ionizing, pubmed-meshheading:21405945-Tumor Suppressor Proteins
pubmed:year	2011
pubmed:articleTitle	Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.
pubmed:affiliation	Centro Ricerca S. Pietro, Fatebenefratelli Hospital, Via Cassia 600, Rome, Italy.
pubmed:publicationType	Journal Article